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KMID : 0378019910340040067
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New Medical Journal
1991 Volume.34 No. 4 p.67 ~ p.70
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Clinical Study on the Effect of Fraxiparine^(®) After Micro-vascular Surgery
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Abstract
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Performing microvascular surgery, the anastomosed vessels were often obstructed with thrombosis in the postoperative period. Endothelial damage of anastomosed vessels and change of blood flow and components are regarded as predisposing to thrombosis of the anastomosed vessels. Generally, the heparin has been used for prevention of thrombus formation, but when the doses are high, incurs an appreciable risk of hemorrhage and severe thrombopenia.
Fraxiparine consisting of sulfated glycosaminoglycan chains derived from heparin, is a new therapeutic agent with high antithrombotic activity without attendant anticoagulant activity.
The author administrated Fraxiparine to the patients who were undertaken microvascular anastomosis and the results were as follows
1. The vascular status is the most important factor affecting postoperative results.
2.. In severe injured cases, ancillary pharmacologic agent therapy can increase the patency rate of the vessel and decrease the number of secondary operation.
3.. Fraxiparine is a safe antithrombotic agent in clinical dose without attendant anticoagulant activity.
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